While writing a series of articles about horrible murders in the Low Side District of New York, the young reporter, Jimmy Palmer, will soon become involved in a game of cat and mouse with an illusive and deadly character--Jack the Ripper. Along Palmer's dark journey he will foster a friendship with a young singer, Abigail, the "Irish Nightingale," and meet numerous other colorful characters of this poor district.

Beginning with the search of witnesses to the crimes, Palmer's snooping will soon lead him to investigate suspects. His daily editorials trigger the interest of the serial killer himself, who begins to correspond with Palmer via the newspaper, leading Palmer to surmise that this killer is the infamous Jack the Ripper!