The Evil Mad Scientist is fed up with the Looney Tunes and plans to get rid of them once and for all. Using his homemade time machine and giant ACME eraser, he will travel through time and erase the Looney Tunes and their ancestors from existance. Little does he know though that the Looney Tunes have built their own time machine, and will fight the Evil Mad Scientist to save themselves from disappearing.

Looney Tunes: Acme Arsenal is an action-adventure game featuring seven playable Looney Tunes characters, including Bugs Bunny, Daffy Duck, Tazmanian Devil, Foghorn Leghorn, Marvin the Martian, Gossamer and a special secret character, all rendered in high-definition, next-generation graphics. Gamers find themselves immersed in combat, puzzles, and vehicle-based action. Players also command an arsenal of ACME melee and projectile weapons in outrageous battles and travel to various locations such as Camelot, Ancient Egypt, Mars, and the Wild West.